Infectious diseases continue to affect millions of people around the world every year, despite the progress in science and medicine. This presentation will provide an overview of our research team’s work on modeling various of infectious diseases, such as pandemic flu, cholera, malaria, polio, Guinea worm, and Covid-19. To understand the spread of infectious diseases and evaluate the impact of interventions, we utilized different modeling approaches, such as SEIR or agent-based, depending on the research questions or decision-support needs in practice. Our research results provide insights to decision-makers regarding the impact of combinations of interventions, considering factors such as compliance with public health recommendations, as well as the allocation of scare resources such as vaccines.