INFORMS Open Forum

Topic: INFORMS Pacific Northwest - Upcoming Event 

1.  INFORMS Pacific Northwest - Upcoming Event

Posted 18 days ago

Dear Analytics and Operations Research Professionals in the Pacific Northwest Region,

On behalf of the Pacific Northwest Chapter of INFORMS, I am excited to announce the second event of our new presentation series in 2018. These events are great opportunities for professionals and graduate students in analytics, data science, operations research and management sciences to meet, network, learn and share knowledge.

Title: Utilizing Simulation and Optimization Techniques to Evaluate Different Car-T Cell Therapy Manufacturing Paradigms


Presented by: Dr. Olga Raskina: Senior Operations Research Scientist – Juno Therapeutics


Location: University of Washington, Foster School of Business, Paccar Hall 394.


Date and Time: March 27th, 2018. 6:30 – 8 PM.


Abstract: Juno Therapeutics is a clinical-stage cell immunotherapy company focused on revolutionizing medicine by re-engaging the body's immune system to treat cancer. In an effort to understand major cost drivers and assess processing risk, Juno Therapeutics has developed a plant simulation of its global manufacturing network.  With this simulation, Juno can assess the impact various control levers and sources of variability will have on key performance metrics.  Juno has the ability to modify various aspects of its manufacturing operations, such as process design, staffing totals, shift schedules, facility configuration, and activity prioritization.  Various sources of variability, such as time of patient specific raw material arrival at the plant, treatment rescheduling, and unit operation duration, will need to be mitigated in order to ensure robust manufacturing.  In turn, with a representative simulation in place, optimization techniques can be leveraged in an effort to maximize the number of treated patients and revenue, while minimizing cost of goods and product cycle time.  This work helps inform feasibility of future manufacturing paradigms and process design.  An overview of Juno's simulation and optimization methodology is presented here.  Evaluations and trade-offs of point-of-care vs. centralized manufacturing and fixed workstation vs. flexible facility configurations are presented.


Bio: Olga Raskina is a Senior Operations Research Scientist in the Supply Chain organization at Juno Therapeutics. Olga is responsible for all OR related projects at Juno, primarily focusing on the design and operation of Juno's manufacturing facilities as well cost reduction opportunity analysis. Prior to joining Juno Olga led multiple network and revenue optimization projects at national transportation provider. Olga's past INFORMS-related activities include: past VP of Chapters/Fora at the INFORMs board; past judge at the Student Analytics competition; member of the UPS prize committee; member of the Engagement with Organizations committee; member of the Membership committee.

Shervin Beygi
Data Scientist
Seattle WA